Workpackage number 3 (WP3)
Leader: UKON (Prof. A. Buerkle)
Oxidative stress and stress-related proteins
Participants: UKON, MUL, INRCA, NHRF, UNIROMA3, UP7DD, SE, UNIPG.
Objectives:
WP3 will be focussed on oxidative stress, on several zinc-dependent stress related proteins (PARP-1, ApoJ, MT, NO, chaperones) and the activity of zinc-dependent (SOD) and other (GPX and catalase) antioxidant enzyme in the elderly, as well as on the role played by the proteasome system in the degradation of some proteins whose abnormal increments are harmful in ageing or eventually the repair of oxidised proteins through peptide methionine sulfoxide reductase (MsrA) activity.