Workpackage number 4 (WP4)

Leader: CNIO (Dr. M. Blasco)

Genome stability and DNA damage/ repair

Participants: CNIO, URC, MUL


WP4 studies genomic stability, interactions between zinc and immune functions at genomic level in relation to DNA damage and its possible correction by in vitro zinc administration. In particular, the zinc-dependent mediators of telomerase-mediated survival and proliferation will be investigated. In addiction, the assessment of DNA damage in lymphocytes of elderly subjects, as well as, protection properties of Zn against DNA damage in lymphocytes will be studied.